Gender	Male
E-mail	hengjun.chao@mssm.edu
Education and Training	M.D., Peking Union Medical College
	M.B., Hunan Medical College
	Postdoctoral Fellowship, University of North Carolina at Chapel Hill

Chao Laboratory

Education and Training	M.D., Peking Union Medical College
	M.B., Hunan Medical College
	Postdoctoral Fellowship, University of North Carolina at Chapel Hill

Dr. Chao is interested in exploration and development of gene therapy for genetic diseases using recombinant adeno-associated virus (AAV) vectors. Current research in Dr. Chao's lab is focusing on two fronts:

1. To investigate mechanisms underlying host immunity and tolerance to FVIII and FIX following AAV-based gene transfer.
2. To develop spliceosome-mediated RNA trans-splicing mediated RNA repair for gene therapy of Duchene Muscular Dystrophy using AAV as the gene transfer vector.

For more information, please visit the Chao Laboratory website.

Chao HJ, Walsh CE. Canine FIX antigen in Chapel Hill strain hemophilia B canine. Haemostasis and Thrombosis 1999; 82: 1378.

Chao HJ, Samulski RJ, Bellinger DA, Monahan PE, Nichols TC, Walsh CE. Persistent expression of cFIX in hemophilia B canines. Gene Ther 1999; 6: 1695-1704.

Chao HJ, Mao L, Bruce AT, Walsh CE. Sustained expression of human factor VIII in mice using a parvovirus-based vector. Blood 2000 Mar; 95(5): 1594-1599.

Chao HJ, Liu Y, Rabinowitz J, Li C, Samulski RJ, Walsh CE. Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors. Mol Ther 2000; 2(6): 619-623.

Chao HJ, Walsh CE. Induction of tolerance to human factor VIII in mice. Blood 2001; 97(10): 3311-2.

Chao HJ, Monahan P, Liu Y, Rabinowitz J, Li C, Samulski J, Walsh CE. Sustained and complete phenotype correction of hemophilia B after direct intramuscular injection of AAV serotype one vectors. Mol Ther 2001; 4(3): 217-222.

Chao HJ, Sun L, Bruce AT, Xiao X, Walsh CE. Expression of human factor VIII by splicing between dimerized AAV vectors. Mol Ther 2002; 5(6): 716-722.