Specialty	Neurological Surgery
Clinical Interests	Brain Cancer
	Brain Tumors
	Brain Mestasis
	Minimally Invasive Brain Surgery
	Meningioma
	Radiosurgery
	Epilepsy Surgery
	Brain Mapping
	Movement Disorders
	Spine Surgery
Languages	English
	French
	German
	Spanish
	Italian
Gender	Female
E-mail	isabelle.germano@mountsinai.org
Education and Training	MD, University of Turin Medical School
	Residency, Neurosurgery, Albert Einstein College of Medicine
	Residency, Neurosurgery, Univ. of California, San Francisco
	Residency, Surgery, Univ. of California, San Francisco
	Fellowship, Neurosurgery, University of Zurich
	Fellowship, Neurosurgery, Montreal Neurological Institute
Awards	2008 - 2012 Research grant: Brain tumors and gene transfer National Institute of Health
	2007 Brain Tumor Research Goldhirsh Foundation
	2006 New York State Certificats of Recognition, Dedication and Service to the Italians Culture and Community New York State
	2006 Life Time Member Who is Who Strathmore's
	2005 Certificate of Excellence in Youth Education New York City Department of Education and Mount Sinai School of Medicine
	2004 Neurosurgery Research Award New York State Society
	2002 - 2006 America's Top Cancer Doctors Castle Connolly
	2000 - 2006 Top Doctors New York Metro Area Castle Connolly
	2000 - 2006 America's Top Doctors 1-5th edition Castle Connolly
	2000 - 2006 Best Doctors Of New York New York Magazine

Dr. Germano joined the faculty at Mount Sinai in 1993. Her specialty interests include Brain Tumors, Computer-Assisted Image-Guided Neurosurgery, Parkinson's disease and Movement Disorders, Epilepsy and Radiosurgery. She is Director of The Mount Sinai Medical Center Stereotactic and Brain Tumor Program, an advanced multidisciplinary program based on computer-assisted image-guided neurosurgery and brain mapping to accomplish minimally invasive procedures and treatment of brain tumors. Dr. Germano is one of the pioneers of computer-assisted image-guided neurosurgery. This sophisticated technology, including the Novalis Shaped Beam Surgery, is used to perform minimally invasive surgery for patients with brain tumors, epilepsy, Parkinson's disease and movement disorders. Active in national neurosurgery organizations, she has served as an executive committee member for the Congress of Neurosurgery (CNS), as a Board of Directors' member for the American Association of Neurological Surgeons, as an executive committee member of the AANS/CNS Joint Section on Tumors, and as a scientific program member for the AANS, CNS, and the American Epilepsy Society. For the past five years she has directed a course, Advanced Techniques in Image-Guided Brain and Spine Surgery, for neurosurgeons from around the country.

In the News

Dr. Germano and her work diagnosing and treating brain tumors were recently profiled in The Daily News feature The Daily Check Up. View the PDF.

Education and Training	MD, University of Turin Medical School
	Residency, Neurosurgery, Albert Einstein College of Medicine
	Residency, Neurosurgery, Univ. of California, San Francisco
	Residency, Surgery, Univ. of California, San Francisco
	Fellowship, Neurosurgery, University of Zurich
	Fellowship, Neurosurgery, Montreal Neurological Institute
Board Certification	Neurological Surgery

Specialty	Neurological Surgery
Clinical Interests	Brain Cancer
	Brain Tumors
	Brain Mestasis
	Minimally Invasive Brain Surgery
	Meningioma
	Radiosurgery
	Epilepsy Surgery
	Brain Mapping
	Movement Disorders
	Spine Surgery
Languages	English
	French
	German
	Spanish
	Italian
Board Certification	Neurological Surgery

Translational research for malignant brain tumors
The main focus of the laboratory is to investigate new strategies for adjuvant treatment of malignant brain tumors. With the support from the National Institutes of Health, NIH, private foundations and Industry, the laboratory has been very productive in investigating new promising modalities and compound to kill brain tumor cells. Embryonic stem cells are currently used in animal models to transfer genes to brain tumors.

Image-guide computer-assisted neurosurgery
One of the pioneers in this field, Dr. Germano continues to collaborate with the industry in making neurosurgical resections more accurate and less invasive.

Related Link:
Brain Tumor and Gene Therapy Laboratory

Uzzaman M, Keller G, Germano I. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology 2008;.

Benzil D, Abosch A, Germano IM, Gilmer H, Maraire N, Muraszko K, Pannullo S, Rosseau G, Schwartz L, Todor R, Ullman J, Zusman E. The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery. J Neurosurgery 2008; 109: 367-375.

Germano IM, Uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant gliomas. Cancer Biology and Therapy 2008; 7: 81-87.

Uzzaman M, Keller G, Germano IM. Enhanced pro-apotptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on temozolomide-resistant glioma cells. J Neurosurgery 2007; 106: 646-651.

Germano I, Uzzaman M, Benveniste R, Zaurova M, Keller G. Apoptosis in human glioma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Neurosurgery 2006; 105: 88-95.

Uzzaman M, Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes: novel gene therapy vector for brain tumors. Neurosurgical Focus 2005; 19(3): E6.

Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: Differentiation and allotransplantation into the mouse brain. J Neurosurgery 2005; 103: 115-123.

Benveniste R, Germano IM. Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques. Surg Neurol 2005; 63: 542-549.

Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein BNIP3. Oncogene 2005; 24: 980-991.

Germano IM, Gracies JM, Weisz DJ, Tse W, Koller WC, Olanow CW. Unilateral stimulation of the subthalamic nucleus in Parkinson's disease- a double blind 12-month evaluation study. J Neurosurgery 2004; 101: 36-42.