Intracranial Hemorrhage Outcomes Project (IHOP) - (GCO# 07-1321)

This is a prospective study enrolling neuro-intensive care patients that present with spontaneous subarachnoid hemorrhage, subdural hemorrhage or intracerebral hemorrhage. This is an observational trial in which information about consenting patient’s demographics, past medical and surgical history, functional status, admission exam, imaging, and hospital course is entered into a secure database. Details of any procedures the patient may receive will be recorded. Patients enrolled in the study will be contacted by our team at three months and one year after hospital admission for follow up on their functional and cognitive status. This study entails minimal risk to subjects (all data is stored anonymously) and benefits subjects by providing free follow-up with our team during the recovery phase of illness.

Inclusion Criteria:

1. Males and females aged 18 years or older
2. Intracranial hemorrhage including spontaneous SAH, ICH or SDH diagnosed by CT or lumbar puncture,
3. Signed informed consent, and Health Insurance Portability and Accountability Act (HIPAA) forms

Exclusion Criteria:

1. Age: 18 or younger
2. Traumatic SAH

Prediction of Postoperative Recurrence of Subdural Hematoma using CT Perfusion - (GCO#08-1470)

This is a prospective study enrolling neuro-intensive care patients that present with subdural hemorrhage (SDH). Our clinical protocol for management of SDH entails serial CT/CT perfusion scanning (three scans total). Patients enrolled in this study are followed in a similar fashion to the IHOP trial and undergo functional and cognitive assessments at three months and one year after hospital admission. CT/CT perfusion scans will be rated using a novel system by a blinded neuro-radiologist.

Inclusion Criteria:

1. Males and females aged ≥ 18 years
2. Subdural hemorrhage diagnosed by CT or MRI
3. Signed informed consent, and Health Insurance Portability and Accountability Act (HIPAA) forms

Exclusion Criteria:

1. Aged <18 years
2. Pregnancy
3. Allergy to iodinated contrast
4. Serum creatnine>1.5 at baseline (in a patient not on dialysis)
5. Oliguria in a non-dialysis dependent patient or evidence of acute kidney injury or acute renal failure
6. GFR<30
7. Volume depletion
8. Multiple myeloma
9. Diabetic nephropathy