The contribution of dyslipidemia to cardiovascular disease in the renal disease population

The most common cause for mortality in the end-stage renal disease patients is cardiovascular disease. My previous research investigated the putative roles of molecular chaperones in apolipoprotein B metabolism, the primary protein moiety of the LDL and VLDL lipoproteins. Among the molecules studied were gp78, cdc97, microsomal triglyceride transfer protein and their respective mechanisms at the cellular and molecular levels.

Currently the goal is to integrate this basic science with patient care and to develop a clinical trial.

Wei G, Lonardo F, Ueda T, Kim T, Huvos AG, Healy JH, Ladanyi M. CDK4 Gene Amplification in Osteosarcoma: Reciprocal Relationship in INK 4A Gene Alterations and Mapping of 12q13 Amplicons. International Journal of Cancer 1999; 80: 199-204.

Jones S, Kim T. Fulminant Leptospirosis in a Patient with Human Immunodeficiency Virus Infection: Case Report and Review of Literature. Clinical Infectious Diseases 2001 Sep 1; 33(5): E31-33.

Liang J, Kim T, Fang S, Yamaguchi J, Weissman A, Fisher E, Ginsberg H. Overexpression of theTumor Autocrine Motility Factor Receptor gp78, a Ubiquitin Protein Ligase, Results in Increased Ubiquitylation and Decreased Secretion of Apolipoprotein B100 in HepG2 Cells. J Biol Chem 2003; 278(26): 23984-23988.