Overview
| Specialty |
Neurological Surgery
|
| Clinical Interests |
Minimally Invasive Spine Surgery |
| |
Brain Tumors |
| |
Skull Based Surgery |
| |
Meningioma |
| |
Herniated Disc |
| |
Degenerative Spinal Disorders |
| |
Radiosurgery |
| Languages |
English |
| |
Chinese (Mandarin) |
| Gender |
Female |
| E-mail |
hongyan.zou@mountsinai.org |
| Education and Training |
MD, Stanford University Hospital |
| |
Internship, General Surgery, Stanford University Hospital |
| |
Residency, Neurosurgery, Stanford University Hospital |
| Awards |
2007
Congress of Neurological Surgeons Resident Award |
| |
2006
NRSA/NINDS Postdoctoral Fellowship |
| |
2000
Baxter Foundation Grant |
| |
1996
Julian R. Rachele Prize |
| |
1996
Frank Lappin Horsfall Jr. Fellowship |
Dr. Zou focuses her clinical practice in minimally-invasive and complex spine, brain and spine tumors and general neurosurgery. Her laboratory studies the molecular mechanisms of axonal growth and neurogenesis. Her research will support the development of molecular treatments for neuronal and axonal regeneration.
Please visit Dr.
Hongyan Zou's
Laboratory of Axon Growth
and Neuronal Regeneration for more information.
Research
Research
Specific Research Interests:
-Molecular mechanisms of axonal growth;
-Transcription factors regulating axonal regeneration;
-Neural stem cell proliferation, differentiation and implication in CNS tumorigenesis.
Our lab is interested in understanding how neurons are born, how they extend axons, and how they regenerate or fail to regenerate after injury. Brain and spinal cord injuries account for billions of dollars each year in medical costs. Understanding classic and identifying novel signaling pathways that promote neurogenesis and axonogenesis will provide new molecular targets towards effective CNS regeneration. Similar mechanisms that regulate the neural stem cell (NSC) niche also regulate tumor stem cells (TSCs). Developing strategies to shrink the TSC pool by inhibiting proliferation, inducing apoptosis or promoting differentiation will have great impact on treating primary brain tumor, which is one of the leading causes of death in children and young adults.
Publications
Zou H, Ho C, Wong K, Tessier-Lavigne M. Axotomy-induced Smad1 Activation Promotes Axonal Growth in Adult Sensory Neurons. Journal of Neuroscience 2009; 29(22): 7116-7123.
Varley JE, McPherson CE, Zou H, Niswander L, Maxwell GD. Expression of a constitutively active type I BMP receptor using a retroviral vector promotes the development of adrenergic cells in neural crest cultures. Developmental Biology 1998 Apr 1; 196(1): 107-118.
Zou H, Wieser R, Massague J, Niswander L. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes & Development 1997 Sep 1; 11(17): 2191-2203.
Zou H, Choe KM, Lu Y, Massague J, Niswander L. BMP signaling and vertebrate limb development. Cold Spring Harbor Symposia on Quantitative Biology 1997; 62: 269-272.
Zou H, Niswander L. Requirement for BMP signaling in interdigital apoptosis and scale formation. Science 1996 May 3; 272: 738-741.
