Gender	Female
E-mail	chunli.yu@mssm.edu
Education and Training	B.S., Peking University
	M.D., Peking Union Medical College
	Residency, Peking Union Hospital
	Postdoctoral fellow, Yale University

Education and Training	B.S., Peking University
	M.D., Peking Union Medical College
	Residency, Peking Union Hospital
	Postdoctoral fellow, Yale University

Laboratory diagnosis of inborn errors of metabolism

My main mission is to build state-of-art biochemical genetics laboratory at Mount Sinai.  I will bring the most updated tandem mass spectrometry technology into biochemical genetics laboratory.  We will expand diagnostic panel from amino acids, organic acids disorders to fatty acids oxidation disorders and all other NBS disorders.  We will transform the wet chemistry bench tradition into high-through put, automated, IT intelligent and technology driven laboratory platform.  In concert with departmental research expertise, we will develop our unique diagnostic testing in Porphyria, LSDs, and pharmacokinetics/dynamics of Warfarin and Tamoxifen. 

Gregory CO, Yu C, Singh RH. Blood phenylalanine monitoring for dietary compliance among patients with phenylketonuria: comparison of methods. Genet Med 2007 Nov; 9(11): 761-765.

Coffee B, Hjelm LN, DeLorenzo A, Courtney EM, Yu C, Muralidharan K. Characterization of an unusual deletion of the galactose-1-phosphate uridyl transferase (GALT) gene. Genet Med 2006 Oct; 8(10): 635-640.

Kim JK, Fillmore JJ, Gavrilova O, Chao L, Higashimori T, Choi H, Kim HJ, Yu C, Chen Y, Qu X, Haluzik M, Reitman ML, Shulman GI. Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice. Diabetes 2003 Jun; 52(6): 1311-1318.

Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 2002 Dec 27; 277(52): 50230-50236.

Houmard JA, Tanner CJ, Yu C, Cunningham PG, Pories WJ, MacDonald KG, Shulman GI. Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects. Diabetes 2002 Oct; 51(10): 2959-63.

Petersen KF, Oral EA, Dufour S, Befroy D, Ariyan C, Yu C, Cline GW, DePaoli AM, Taylor SI, Gorden P, Shulman GI. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest 2002 May; 109(10): 1345-1350.

Neschen S, Moore I, Regittnig W, Yu CL, Wang Y, Pypaert M, Petersen KF, Shulman GI. Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content. Am J Physiol Endocrinol Metab 2002 Feb; 282(2): E395-E401.

Kim JK, Fillmore JJ, Chen Y, Yu C, Moore IK, Pypaert M, Lutz EP, Kako Y, Velez-Carrasco W, Goldberg IJ, Breslow JL, Shulman GI. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci U S A 2001 Jun 19; 98(13): 7522-7527.

Petersen KF, Laurent D, Yu C, Cline GW, Shulman GI. Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans. Diabetes 2001 Jun; 50(6): 1263-1268.

Rinaldo P, Yoon HR, Yu C, Raymond K, Tiozzo C, Giordano G. Sudden and unexpected neonatal death: a protocol for the postmortem diagnosis of fatty acid oxidation disorders. Semin Perinatol 1999 Apr; 23(2): 204-210.