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Steven J. Burakoff

PROFESSOR  Medicine, Hematology and Medical Oncology
PROFESSOR  Oncological Sciences

Overview

Specialty Internal Medicine
Gender Male
E-mail steven.burakoff@mssm.edu
Education and Training MD, Albany Medical College
  M.D., Albany Medical College
  MA (hon.), Harvard University
  MA, Queens College
  Internship and Residency, New York Hospital-Cornell Medical Center
  Fellowship, Rockefeller University
  Fellowship, Harvard Medical School
  Internship, General Medicine, Cornell Medical Center
  Residency, General Medicine, Cornell Medical Center
  Fellowship, Immunology, Rockefeller University
Awards 2009
Lifetime Achievement Award
American Association of Immunologists
  2006
Lynne Cohen Foundation Awardee
  2003
Distinguished Alumnus 2003
Albany Medical College Alumni
  2002
Theobold Smith Alumni Lecture
Albany Medical College
  2001
ISI Highly Cited Researcher (1980-2000)
  2000
Laura and Isaac Perlmutter Professor
New York University, School of Medicine
  1998
Margaret M. Dyson Professor of Pediatrics
Harvard Medical School
  1995
Association of American Physicians
  1995
Ted Williams Senior Investigator
Dana-Farber Cancer Institute
  1994
Horizons in Biomedical Research Lecture
Cleveland Clinic Foundation
  1992
David A. Talmadge Lecture
Colorado Allergy Society

Dr. Burakoff is the Director of The Tisch Cancer Institute at Mount Sinai Medical Center; Lillian and Henry M. Stratton Professor of Cancer Medicine;  Professor of Medicine, Hematology and Medical Oncology; and Professor, Oncological Sciences.

Training

Education and Training MD, Albany Medical College
  M.D., Albany Medical College
  MA (hon.), Harvard University
  MA, Queens College
  Internship and Residency, New York Hospital-Cornell Medical Center
  Fellowship, Rockefeller University
  Fellowship, Harvard Medical School
  Internship, General Medicine, Cornell Medical Center
  Residency, General Medicine, Cornell Medical Center
  Fellowship, Immunology, Rockefeller University
Board Certification Internal Medicine

Clinical Practice

Specialty Internal Medicine
Board Certification Internal Medicine

Research

Major Research Interests:

   1. Cellular and molecular immunology;
   2. T cell activation and signal transduction;
   3. Transplantation immunology.

Publications

Jin YJ, Cai CY, Zhang X, Zhang HT, Burakoff SJ. Lysine144, a Ubiquitin Attachment Site in HIV-1 Nef, Is Required for Nef-mediated CD4 Downregulation. J Immunol 2008;.


Sawasdikosol S, Pyarajan S, Alzabin S, Matejovic G, Burakoff SJ. Prostaglandin E2 activates HPK1 activity via a PKA-dependent pathway. J Biol Chem 2007 Nov; 282: 34693-34699.


Mathews JP, Taylor BS, Bader GD, Pyarajan S, Antoniotti M, Chinnaiyan AM, Sander C, Burakoff SJ, Mishra B. From bytes to bedside: data integration and computational biologyfor translational cancer research. PLoS Comput Biol 2007 Feb 23; 3(2): e12.


Fragoso R, Pyarajan S, Irie HY, Burakoff SJ. CD8/Lck transgene is able to drive thymocyte differentiation. J. Immun 2006 Feb 15; 176(4): 2669.


Jin JJ, Yi Cai C, Zhang X, Zhang HT, Hirst JA, Burakoff SJ. HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent. J. Immun 2006 Feb 15; 176(4): 2669.


Zambricki E, Shigeoka A, Kishimoto H, Sprent J, Burakoff S, Carpenter C, Milford E, McKay D. Signaling T cell survival and death by IL-2 and IL-15. Am J Transplant 2005; 11: 2623-2631.


Su MW, Pyarajan S, Chang JH, Yu CL, Jin YJ, Stierhof YD, Walden P, Burakoff SJ. Fratricide of CD8+ cytotoxic T Lymphocytes is dependent on cellular activation and perforin-mediated killing. Eur J Immunol 2004; 34: 2459-2470.


Frazer-Abel AA, Baksh S, Fosmire SP, Willis D, Pierce AM, Meylemans H, Linthicum DS, Burakoff SJ, Coons T, Bellgrau D. Nicotine activates NFATc2 and prevents cell cycle entry in T cells. J Pharmacol Exp Ther 2004; 311: 758-769.


Friedman JS, Alpdogan O, van den Brink MR, Liu C, Hurwiz D, Boyd A, Kupper TS, Burakoff SJ. Increasing T cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model. Biol Blood Marrow Transplant 2004; 10: 448-460.


Friedman JS, Lopez MF, Fleming MD, Rivera A, Martin FM, Welsh ML, Boyd AS, Doctrow SR, Burakoff SJ. SOD2 Deficiently anemia: protein oxidation and altered protein expression reveal targets of damage, stress response and anti -oxidant responsiveness. Blood 2004; 104: 2565-2573.


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