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Anna Rita Migliaccio

PROFESSOR  Medicine, Hematology and Medical Oncology

Overview

Gender Female
E-mail annarita.migliaccio@mssm.edu
Education and Training Ph.D., University of Naples (Naples, Italy)
  Ph.D., University of Naples (Naples, Italy)
  EORTC Fellowship, University of Washington (Seattle, WA)
  EURATOM Fellowship, Radiobiological Institute, TNO (Rijswiik, The Netherlands)
Awards 2008 - 2013
Editorial Board
Blood
  2007 - Present
Editorial Board
Leukemia
  2005 - Present
Editorial Board
Stem Cells
  1994 - 1999
Editorial Board
Blood
  1992 - 1995
Editorial Board
Experimental Hematology
  1992 - 1995
Editorial Board
International Journal Hematology

Training

Education and Training Ph.D., University of Naples (Naples, Italy)
  Ph.D., University of Naples (Naples, Italy)
  EORTC Fellowship, University of Washington (Seattle, WA)
  EURATOM Fellowship, Radiobiological Institute, TNO (Rijswiik, The Netherlands)

Research

2004-2009
Member of the Program for Excellency in Training  "Eurythron"  European Community
The scope of this project is to establish a multicenter excellence training program in Experimental Hematology
 

2006-2010
P01-CA108671-04
"Mouse models of Myelofibrosis"
The scope of this project is to exploit the Gata1low mouse model to detail the pathobiological pathway  leading to development of increased stem/progenitor cell trafficking and extramedullary hematopoiesis in myleofibrosis

2007-2010
New York State Star Program:
 "Personalized Therapies for Sickle Cell Disease and Thalassemia."
The scope of this project is to develop in vitro assays to predict the response to therapy with histone deacetylase inhibitors of sickle cell and thalassemia patients.  

Publications

Ghinassi B, Sanchez M, Martelli F, Amabile G, Vannucchi AM, Migliaccio M, Orkin SH, Migliaccio AR. The hypomorphic Gata1low mutation alters the proliferation/ differentiation potential of the common megakaryocytic-erythroid progenitor. Blood 2007; 109: 1460-1471.


Martelli F, Ghinassi B, Panetta B, Alfani E, Gatta V, Pancrazzi A, Bogani C, Vannucchi AM, Paoletti F, Migliaccio G, Migliaccio AR. Variegation of the phenotype induced by the GATA-1low mutation in mice of different genetic background. Blood 2005; 106: 4102-4113.


Vannucchi AM, Bianchi L, Paoletti F, Pancrazi A, Torre E, Nishikawa M, Zingariello M, Di Baldassarre A, Rana RA, Lorenzini R, Alfani E, Migliaccio G, Migliaccio AR. A patho-biological pathway linking thrombopoietin, GATA-1 and TGF-B1 in the development of myelofibrosis. Blood 2005; 105: 3493-3501.


Centurione L, Di Baldassarre A, Zingariello M, Bosco D, Gatta V, Rana RA, Langella V, Di Virgilio A, Vannucchi AM, Migliaccio AR. Increased and pathological emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1low mice. Blood 2004; 104: 3573-3579.


Migliaccio AR, Rana RA, Sanchez M, Lorenzini R, Migliaccio G, Orkin SH. GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-low mouse mutant. J Exp Med 2003; 197: 281-296.


Vannucchi A, Bianchi L, Cellai C, Paoletti F, Rana RA, Lorenzini R, Migliaccio G, Migliaccio AR. Development of myelofibrosis in mice genetically impaired for GATA-1 expression (Gata-1low mice). Blood 2002; 100: 1123-1132.


Migliaccio AR, Adamson JW, Stevens CE, Dobrila NL, Carrier CM, Rubinstein P. Cell dose and speed of engraftment in placental/umbilical cord blood transplantation: graft progenitor cell content is a better predictor than nucleated cell dose. Blood 2000; 96: 2717-2722.


Rubinstein P, Carrier C, Scaradavou A, Kurtzberg J, Adamson J, Migliaccio AR, Berkowitz RL, Cabbad M, Dobrilla L, Taylor P, Stevens C. Initial results of the placental/umbilical cord blood program for unrelated bone marrow reconstitution. New Engl J Med 1998; 339: 1565-1577.


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