Research
Specific Clinical/Research Interest: Stem Cells/Microenvironment/Stem Cell NIche, Cell, Developmental, Molecular regulation of hematopoietic stem cell self renewal and differentiation, molecular interaction of stem cells and microenvironmental elements, ie. the stem cell niche regulation of stem cells.
Current Students: Jiajing Qiu
Postdoctoral Fellows: Dario Sirabella
Research Personnel: Xiaohong Niu
Summary of Research Studies:
Primary research interest in defining the cellular and molecular nature of the hematopoietic stem cell niche, particularly the molecular cross-talk between stem cells and their niche. First approach a genomic profile of a stem cell supporting stromal cell line. Profile led to mouse models that manipulate and allow visualization of stem cells in their niche. These models are ready for publication and manuscripts are being prepared.
Publications
Moore KA, Lemischka IR. Stem cells and their niches. Science 2006 Mar 31; 311(5769): 1880-1885.
Ivanova NB, Dimos JT, Schaniel C, Hackney JA, Moore KA, Lemischka IR. A stem cell molecular signature. Science 2002 Oct 18; 298(5593): 601-604.
Hackney JA, Charbord P, Brunk BP, Stoeckert CJ, Lemischka IR, Moore KA. A molecular profile of a hematopoietic stem cell niche. Proc Natl Acad Sci U S A 2002 Oct 1; 99(20): 13061-13066.
Phillips RL, Ernst RE, Brunk B, Ivanova N, Mahan MA, Deanehan JK, Moore KA, Overton GC, Lemischka IR. The genetic program of hematopoietic stem cells. Science 2000 Jun 2; 288(5471): 1635-1640.
Moore KA, Ema H, Lemischka IR. In vitro maintenance of highly purified, transplantable hematopoietic stem cells. Blood 1997 Jun 15; 89(12): 4337-4347.
Moore KA, Pytowski B, Witte L, Hicklin D, Lemischka IR. Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs. Proc Natl Acad Sci USA 1997 Apr 15; 94(8): 4011-4016.