Subspecialty	Endocrinology, Diabetes and Metabolism
Gender	Male
E-mail	christoph.buettner@mssm.edu
Education and Training	MD, Ludwig Maximilians Universitat
	Internship, Internal Medicine, Ludwig Maximilians Universitat
	Residency, Internal Medicine, New York University School of Medicine
	Fellowship, Endocrinology, Montefiore Medical Group

Education and Training	MD, Ludwig Maximilians Universitat
	Internship, Internal Medicine, Ludwig Maximilians Universitat
	Residency, Internal Medicine, New York University School of Medicine
	Fellowship, Endocrinology, Montefiore Medical Group
Board Certification	Endocrinology, Diabetes and Metabolism

Subspecialty	Endocrinology, Diabetes and Metabolism
Board Certification	Endocrinology, Diabetes and Metabolism

New topic
Our interest is to understand how hormones and nutrients are sensed by the hyopothalamus and how the brain controls systemic metabolism. In the obesity and in type 2 diabetes this brain control of metabolism is impaired and we believe this dysfunction plays an important role in the pathogenesis of both of these conditions. Interestingly, diabetes and obesity are associated with a pro-inflammatory state. We have found that hormones like insulin and leptin regulate systemic inflammation via the brain and the autonomic nervous system and speculate that this may be the basis for the link between impaired metabolic control and inflammation. A commonly used approach in our lab is to study nutrient fluxes with clamp studies combined with metabolic tracers in rodents.

Li JH, Gautam D, Han SJ, Guettier JM, Cui Y, Lu H, Deng C, O'Hare J, Jou W, Gavrilova O, Buettner C, Wess J. Hepatic Muscarinic Acetylcholine Receptors are not Critically involved in Maitning Glucose Homeostasis in Mice. Diabetes 2009 September;.

Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, Budagov T, Cui L, Einstein FH, Poduval A, Hwang D, Barzilai N, Cohen P, . Humanin: A Novel Central Regulator of Peripheral Insulin Action.. PloS One 2009 July; 4(7): e6334.

Scherer T, Buettner C. The Dysregulation of the Endocannabinoid System in Diabesity-a Tricky Problem. J Mol Med 2009 March;.

Buettner C, Camacho RC. Hypothalamic Control of hepatic Glucose Production and Its Potential Role in Insulin Resistance. Endocrinol Metab Clin North Am 2008 December; 37(4): 825-840.

Osei-Hyiaman D, Liu J, Zhou L, Godlewski G, Harvey-White J, Jeong WI, Batkai S, Marsicano G, Lutz B, Buettner C, Kunos G, . Hepatic CB1 Receptor is Required for Development of Diet-Induced Steatosis, Dyslipidemia, and Insulin and Leptin Resistance in Mice. J Clin Invest 2008 September; 118(9): 3160-3169.

Buettner C, Muse ED, Pocai A, Chen A, Kai S, Chen L, Harvey-White J, Kunos G, Rossetti L. Leptin Control Adipose Tissue Endocannabinoids and Lipogenesis Via Central, STAT3 Independent Pathways. Nat. Med 2008 June; 14(6): 667-675.

Buettner C. Does FASing Out New Fat In The Hypothalamus Make You Slim?. Cell Metab 2007 October; 6(4): 249-251.

Buettner C, Pocai A, Muse ED, Etgen A, Myers M, Rossetti L. The Role of Stat3 in The Metabolic Actions of Leptin. Cell Met. 2006 July; 4: 49-60.

Pocai A, Morgan K, Buettner C, Gutierrez-Juarez R, Obici S, Rossetti L. Central Leptin Acutely Reverses Diet-Induced Hepatic Insulin Resistance. Diabetes 2005 Nov; 54(11): 3182-3189.

Severe impairment in Liver Insulin Signaling Fails to Alter Hepatic Insulin Action in Mice. Severe Impairment in Liver Insulin Signaling Fails to Alter Hepatic Insulin Actions in Conscious Mice. J Clin. Invest 2005 May;(115): 1306-1313.