Gender	Male
E-mail	javier.maeso@mssm.edu
Education and Training	Ph.D., University of the Basque Country
	M.Sc., University of the Basque Country
	M.Sc., University of the Basque Country

Education and Training	Ph.D., University of the Basque Country
	M.Sc., University of the Basque Country
	M.Sc., University of the Basque Country

We are interested in investigating the structure and function of G protein-coupled receptors (GPCRs) with the ultimate goal of discovering new drugs for the treatment of neuropsychiatric disorders. Our methods include the coordination of several interdisciplinary approaches in tissue cultures, mouse models, and post-mortem human brain. For more information, please visit the Molecular Pharmacology Laboratory.

Gonzalez-Maeso J, Ang RL, Yuen T, Chan P, Weisstaub NV, Lopez-Gimenez JF, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Filizola M, Meana MM, Sealfon SC. Identification of a serotonin/glutamate receptor complex implicated in psychosis. PMID: 18297054.. Nature 2008; 452: 93-97.

Gonzalez-Maeso J, Weisstaub NV, Zhou M, Chan P, Ivic L, Ang R, Lira A, Bradley-Moore M, Ge Y, Zhou Q, Sealfon SC, Gingrich JA. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. . Neuron 2007; 53: 439-452.

Weisstaub NV, Zhou M, Lira A, Lambe E, Gonzalez-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, Dauer WT, Ansorge MS, Morelli E, Mann JJ, Toth M, Aghajanian G, Sealfon SC, Hen R, Gingrich JA. Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. PMID: 16873667.. Science 2006; 313: 536-540.

Gonzalez-Maeso J, Yuen T, Ebersole BJ, Wurmbach E, Lira A, Zhou M, Weisstaub N, Hen R, Gingrich JA, Sealfon SC. Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex. J Neurosci 2003; 23: 8836-8843.

Gonzalez-Maeso J, Rodriguez-Puertas R, Meana JJ, Garcia-Sevilla JA, Guimon J. Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors. Mol Psychiatry 2002; 7: 755-767.