| Gender | Male |
|---|---|
| rauf.latif@mssm.edu | |
| Education and Training | Ph.D., Institute of Basic Medical Sciences |
| Fellowship, Weizmann Institute of Science | |
| Research Fellowship, Indian Institute of Science | |
| Awards | 2003 Travel Award The Endocrine Society |
| 2000 Travel Award The American Thyroid Association |
|
| 1986 Five year Predoctoral Fellowship University Grants Commission, India |
| Education and Training | Ph.D., Institute of Basic Medical Sciences |
|---|---|
| Fellowship, Weizmann Institute of Science | |
| Research Fellowship, Indian Institute of Science |
The thyroid stimulating hormone receptor (TSHR) expressed on the plasma membrane of thyroid epithelial cells is central to the regulation of thyroid growth and function. TSHR undergoes complex post-translational processing such as 1) intra-molecular cleavage of the receptors into covalently linked α and β subunits and 2) homo-oligomerization. Our focus is on understanding the role of these post-translational modifications on receptor regulation and signaling using biochemical and biophysical approaches. Understanding these regulations is important in thyroid autoimmune diseases and thyroid development.
Morshed SA, Latif R, Davies TF. Characterization of thyrotropin receptor antibody-induced signaling cascades. Endocrinology 2009; 150: 519-529.
Sun L, Vukicevic S, Baliram R, Yang G, Sendak R, McPherson J, Zhu LL, Iqbal J, Latif R, Natrajan A, Arabi A, Yamoah K, Moonga BS, Gabet Y, Davies TF, Bab I, Abe E, Sampath K, Zaidi M. Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss. Proc Natl Acad Sci U S A 2008; 105: 4289-4294.
Ando T, Latif R, Davies TF. Antibody-induced modulation of TSH receptor post-translational processing. J Endocrinol 2007; 195: 179-186.
Latif R, Ando T, Davies TF. Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation. Endocrinology 2007; 148: 3164-3175.
Ando T, Latif R, Davies T. Concentration-dependent regulation of thyrotropin receptor function by thyroid-stimulating antibody. JCI 2004; 113: 1589-1595.
Latif R, Ando T, Daniel S, Davies TF. Localization and Regulation of Thyrotropin Receptors within Lipid Rafts. Endocrinology 2003; 144: 4725-4728.
Ciullo I, Latif R, Graves P, Davies TF. Functional assessment of the thyrotropin receptor-beta subunit. Endocrinology 2003; 144: 3176-3181.
Latif R, Graves P, Davies TF. Ligand-dependent inhibition of oligomerization at the human thyrotropin receptor. J Biol.Chem 2002; 277: 45059-45067.
Ando T, Latif R, Pritsker A, Moran T, Nagayama Y, Davies TF. A monoclonal thyroid-stimulating antibody. J Clin Invest 2002; 110: 1667-1674.
Davies T, Marians R, Latif R, . The TSH receptor reveals itself. J.Clin.Invest 2002; 110: 161-164.
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