The Cardiovascular Pathology Laboratory is dedicated to supporting the morphological studies of the CVI fellows and investigators. Major laboratory interests and collaborations are in the areas of arterial thrombosis, vascular injury, atherosclerosis progression and regression, and the use of magnetic resonance imaging techniques experimentally and clinically. We work with individual investigators to plan and carry out their morphological studies from fixation to image data reduction. While the laboratory personnel perform routine histology, immunohistochemistry, digital imaging, morphometric analysis, in situ hybridization, and electron microscopy, we attempt to involve the investigators in the actual work. In particular, investigators learn how to perform microscopic digital imaging and to use the images to obtain quantitative data using computer based morphometric techniques. Our laboratory also serves as a resource for human cardiovascular tissues obtained from surgery or autopsies. Shown here is an example of immunohistochemical staining of human atherosclerotic plaque tissue for the recently discovered cytokine I-309 (A,C,E,G) and a comparison in adjacent histological sections with Apo(a) localization in work done with Dr. Peter Harpel.

Fayad ZA, Fallon JT, Shinnar M, Wehrli S, Dansky HM, Poon M, Badimon JJ, Charlton SA, Fisher EA, Breslow JL, Fuster V. Noninvasive In vivo high-resolution magnetic resonance imaging of atherosclerotic lesions in genetically engineered mice. Circulation 1998; 98: 1541-1547.

Haque N, Zhang X, French D, Li J, Poon M, Fallon J, Gabel BR, Taubman M, Harpel P. CC chemokine I-309 is the principal monocyte chemoattractant induced by apolipoprotein(a) in human vascular endothelial cells. Circulation 2000 Aug 15; 102(7): 786-92.