Gender	Male
E-mail	adrian.ting@mssm.edu
Education and Training	PhD, Mayo Clinic
	BA, Luther College
	Postdoctoral, Dept. of Genetics, Harvard Medical School

Education and Training	PhD, Mayo Clinic
	BA, Luther College
	Postdoctoral, Dept. of Genetics, Harvard Medical School

Research

Specific Clinical/Research Interest:
Antiviral immune response; signal transduction in cell survival and cell death; molecular mechanisms of inflammation
Current Students: Roosevelt Boursiquot (MIC)
Postdoctoral Fellows: Eva Perez-Jimenez, Marie Anne O'Donnell, Diana Legarda-Addison
Overview:

The lab has two major areas of interest: (1) dissecting the cell fate decision-making machinery that determines a pro-survival inflammatory versus a pro-death response following cellular activation by the TNF family of cytokines; (2) understanding the molecular mechanisms underlying the early host response to viral infection.
Summary of Research Studies:
Stimulation of TNF receptor 1 (TNFR1) lead to either cell survival mediated by the NF-kB signaling pathway or to cell death mediated by caspases. We are interested in characterizing the signaling mechanisms that regulate entry into either one of these two divergent signaling pathways. Both transcriptional and post-transcriptional mechanims such as phosphorylation and ubiquitination are being examined. Mutant and knockout cell lines deficient in various components of the TNF pathway are utilized in these studies. A seond area of study in the lab uses a combination of bioinformatics and functional genomics to uncover molecules involved in signaling pathways triggered by intracellular sensors of microbial infections. Several candidate molecules involved in both positive and negative regulation of these innate immune responses are currently being characterized.

Friedman CS, O'Donnell MA, Legarda-Addison D, Ng A, Cardenas WB, Yount JS, Moran TM, Basler CF, Komuro A, Horvath CM, Xavier R, Ting AT. The tumour suppressor CYLD is a negative regulator of RIG-I-mediated anti-viral response. EMBO Reports 2008; 9: 930-936.

Legarda-Addison D, Ting AT. Negative regulation of TCR signaling by NF-kappaB2/p100. J. Immunol 2007; 178: 7767-7778.

O'Donnell MA, Legarda-Addison D, Skountzos P, Yeh WC, Ting AT. Ubiquitination of RIP1 regulates an NF-kappaB-independent cell death switch in TNF signaling. Curr. Biol 2007; 17: 418-424.

Yang M, Hase H, Legarda-Addison D, Varughese L, Seed B, Ting AT. BCMA, the receptor for APRIL and BAFF, induces antigen presentation in B cells. J. Immunol 2005; 175: 2814-2824.

He KL, Ting AT. Essential role for IKK?/NEMO in TCR-induced IL-2 gene expression in Jurkat T cells. Eur. J. Immunol 2003; 33: 1917-1924.

He KL, Ting AT. A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells. Mol. Cell. Biol 2002; 22: 6034-6045.