Gender	Male
E-mail	basil.hanss@mssm.edu
Education and Training	Ph.D., Tulane University
	B.S., Lewis and Clark College
	Fellowship, NIDR/NIH

Curriculum Vitae: http://www.mountsinai.org/supporting-files/cv/hans...

Education and Training	Ph.D., Tulane University
	B.S., Lewis and Clark College
	Fellowship, NIDR/NIH

Characterization of a nucleic acid transporter

The precise molecular mechanism(s) responsible for nucleic acid transport across the plasma membrane are being defined. This research has led to the identification and partial characterization of a plasma membrane protein complex that functions as a highly selective nucleic acid-conducting channel. To date the substrate specificity of the channel has been defined and several channel blockers identified. In addition, three putative channel complex proteins have been cloned. Having now obtained definitive evidence for the role of one of these proteins in channel function future projects focus on definition of the role of the other two proteins. Strategies are being applied to develop a molecular model of nucleic acid transport

Hanss BG, Lewy JE, Vari RC. Alterations in glomerular dynamics in congenital, unilateral hydronephrosis. Kidney Int 1994 Jul; 46(1): 48-57.

Rappaport J, Hanss B, Kopp JB, Copeland TD, Bruggeman LA, Coffman TM, Klotman PE. Transport of phosphorothioate oligonucleotides in kidney: implications for molecular therapy. Kidney Int 1995 May; 47(5): 1462-9.

Leal-Pinto E, Hanss B, Klotman PE. Calcium regulation of a cell surface nucleic acid channel. Kidney Int Suppl 1996 Dec; 57: S4-10.

Lipkowitz MS, Klotman ME, Bruggeman LA, Nicklin P, Hanss B, Rappaport J, Klotman PE. Molecular therapy for renal diseases. Am J Kidney Dis 1996 Oct; 28(4): 475-92.

Hanss B, Stein CA, Klotman PE. Cellular Uptake and Biodistribution of Oligodeoxynucleotides. In: Stein CA, Krieg AM, editors. Applied antisense oligonucleotide technology. New York, Wiley-Liss, Inc.; 1998. pp111-127.

Langer JC, Klotman ME, Hanss B, Tulchin N, Bruggeman LA, Klotman PE, Lipkowitz MS. Adeno-associated virus gene transfer into renal cells: potential for in vivo gene delivery. Exp Nephrol 1998 May-Jun; 6(3): 189-94.

Hanss B, Leal-Pinto E, Bruggeman LA, Copeland TD, Klotman PE. Identification and characterization of a cell membrane nucleic acid channel. Proc Natl Acad Sci USA 1998 Feb 17; 95(4): 1921-6.

Lipkowitz M S, Hanss BG, Tulchin N, Wilson PD, Langer JC, Ross MD, Kurtzman GJ, Klotman PE, Klotman ME. Transduction of renal cells in vitro and in vivo by adeno-associated virus gene therapy vectors. J Am Soc Nephrol 1999 Sep; 10(9): 1908-15.