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Jose A. Moron-Concepcion

INSTRUCTOR  Pharmacology and Systems Therapeutics

Overview

Gender Male
E-mail jose.moron-concepcion@mssm.edu
Education and Training Ph.D., University of Barcelona
  M.Sc., University of Barcelona
  B.Sc., University of Barcelona

Training

Education and Training Ph.D., University of Barcelona
  M.Sc., University of Barcelona
  B.Sc., University of Barcelona

Research

The focus of my research is to study the molecular mechanisms underlying morphine addiction using proteomic tools.

Publications

Moron-Concepcion JA, Perez V, Pasto M, Lizcano JM, Unzeta M. FA-70, a novel selective and irreversible monoamine oxidase-A inhibitor: effect on monoamine metabolism in mouse cerebral cortex. J Pharmacol Exp Ther 2000 Feb ; 292(2): 788-794.


Moron-Concepcion JA, Campillo M, Perez V, Unzeta M, Pardo L. Molecular determinants of MAO selectivity in a series of indolylmethylamine derivatives: biological activities, 3D-QSAR/CoMFA analysis, and computational simulation of ligand recognition. J Med Chem 2000 May 4; 43(9): 1684-1691.


Chefer VI, Moron-Concepcion JA, Hope B, Rea W, Shippenberg TS. Kappa-opioid receptor activation prevents alterations in mesocortical dopamine neurotransmission that occur during abstinence from cocaine. Neuroscience 2000; 101(3): 619-627.


Perez V, Moron-Concepcion JA, Pasto M, Unzeta M. Neuroprotective aspects of a novel MAO-B inhibitor PF9601N. Neurobiology (Bp) 2000; 8(3-4): 231-236.


Daws LC, Callaghan PD, Moron-Concepcion JA, Kalig KM, Shippenberg TS, Javitch JA, Galli A. Cocaine increases dopamine uptake and cell surface expression of dopamine transporters. Biochem Biophys Res Commun 2002 Feb 8; 290(5): 1545-1550.


Carvelli L, Moron-Concepcion JA, Kahlig KM, Ferrer JV, Sen N, Lechleiter JD, Leeb-Lundberg LM, Merrill G, Lafer EM, Ballou LM, Shippenberg TS, Javitch JA, Lin RZ, Galli A. PI 3-kinase regulation of dopamine uptake. J Neurochem 2002 May; 81(4): 859-869.


Moron-Concepcion JA, Brockington A, Wise RA, Rocha BA, Hope BT. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. J Neurosci 2002 Jan 15; 22(2): 389-395.


Moron-Concepcion JA, Zakharova I, Ferrer JV, Merrill GA, Hope B, Lafer EM, Lin ZC, Wang JB, Javitch JA, Galli A, Shippenberg TS. Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity. J Neurosci 2003 Sep 17; 23(24): 8480-8488.


Chefer VI, Czyzyk T, Bolan EA, Moron-Concepcion JA, Pintar JE, Shippenberg TS. Endogenous kappa-opioid receptor systems regulate mesoaccumbal dopamine dynamics and vulnerability to cocaine. J Neurosci 2005 May 18; 25(20): 5029-37.


Garcia BG, Wei Y, Moron-Concepcion JA, Lin RZ, Javitch JA, Galli A. Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Mol Pharmacol 2005 Jul; 68(1): 102-9.


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