Gender	Female
E-mail	camelia.iancu-rubin@mssm.edu
Education and Training	Ph.D., University of Bucharest
	Postdoctoral Training, Mount Sinai School of Medicine
	Fulbright Fellowship, Institute of International Education

Curriculum Vitae: http://www.mountsinai.org/supporting-files/cv/ianc...

Education and Training	Ph.D., University of Bucharest
	Postdoctoral Training, Mount Sinai School of Medicine
	Fulbright Fellowship, Institute of International Education

New topic
Megakaryopoiesis is a complex process in which bone marrow progenitors proliferate and acquire megakaryocyte-specific markers in the early stages, then undergo polyplodization (i.e. multiple rounds of DNA replication in the absence of cell division) and release platelets into the blood circulation in the later stages. The major goal of our research is to understand the mechanisms underlying these processes in normal and malignant megakaryopoiesis. Our first area of investigation is the role of microtubule regulatory protein stathmin in the microtubule-dependent events of megakaryopoiesis, polyploidy and platelet formation. Ongoing studies investigate the effects of lentiviral-mediated stathmin overexpression in megakaryocytes generated ex vivo from bone marrow cells. We are also generating transgenic mice to study the role of stathmin in megakaryopoiesis in vivo. Our second area of investigation is the role of JAK2V617F mutation in abnormal megakaryopoiesis found in myeloproliferative disorders (i.e. essential thrombocythaemia). We currently focus on the effects of JAK2V617F mutation on MK development ex vivo. We are also developing a mouse model in which JAK2V617F mutation would be conditionally expressed in megakaryocytes.

Iancu-Rubin C, Atweh GF. p27Kip1 and Stathmin share the stage for the first time. TRENDS in Cell Biology 2005; 15(7): 346-348.

Iancu-Rubin C, Nasrallah CA, Atweh GF. Stathmin prevents the transition from a normal to an endomitotic cell cycle during megakaryocytic differentiation. Cell Cycle 2005; 4(12): 1774-1782.

Iancu Rubin C, Atweh GF. The Role of Stathmin in the Regulation of the Cell Cycle. J Cell Biochem 2004; 93(2): 242-250.

Iancu Rubin C, French DL, Atweh GF. Stathmin expression and megakaryocyte differentiation: A potential role in polyploidy. Exp Hematol 2003; 31: 389-397.

Iancu C, Mistry SJ, Arkin S, Wallenstein S, Atweh GF. Effects of Stathmin Inhibition on the Mitotic Spindle. J of Cell Sci 2001; 114: 909-916.

Miscalencu D, Iancu C, Mailat F, Nicolae I. Chapter I, MYC Transcription Factors. In: Transcription factors in cancer. Univ of Bucharest, Romania;.

Iancu C, Mistry SJ, Arkin S, Atweh GF. Taxol and Anti-Stathmin Therapy: A Synergistic Combination that Targets the Mitotic spindle. Cancer Research 2000; 60: 3537-3541.