Subspecialty	Medical Oncology
Clinical Interests	Breast Cancer
Gender	Male
E-mail	james.holland@mssm.edu
Education and Training	MD, Columbia University
	Residency, Internal Medicine, Columbia-Presbyterian Medical Center
	Residency, Internal Medicine, Columbia-Presbyterian Medical Center
	Fellowship, Internal Medicine, Francis Delafield Hospital

Dr. Holland is the Distinguished Professor of Neoplastic Diseases.

Education and Training	MD, Columbia University
	Residency, Internal Medicine, Columbia-Presbyterian Medical Center
	Residency, Internal Medicine, Columbia-Presbyterian Medical Center
	Fellowship, Internal Medicine, Francis Delafield Hospital

Subspecialty	Medical Oncology
Clinical Interests	Breast Cancer

Bruckner HW, Wallach R, Cohen CJ, Deppe G, Kabakow B, Ratner LH, Holland JF. Platinum for the Treatment of Refractory Ovarian Cancer. Gynecological Oncology 1981; 12: 64-67.

Plasse T, Ohnuma T, Brooks S, Saponara E, Holland J, Biller H. Bleomycin infusion followed by cyclophosphamide, methotrexate and fluorouracil in advanced squamous carcinoma of the head and neck. Cancer 1984; 53: 841-843.

Kobayashi H, Takemura Y, Holland JF, Ohnuma T. Vincristine saturation of cellular binding sites and its cytotoxic activity in human lymphoblastic leukemia cells: Mechanism of inoculum effect. Biochem Pharmacol 1998; 55: 1229-1234.

Wang FS, Kobayashi H, Liang KW, Holland JF, Ohnuma T. Retrovirus-mediated anti-MDR1 ribozymes fully restores chemosensitivity of P-glycoprotein-expressing human lymphoma cells. Hum Gene Ther 1999; 10: 1185-1195.

Pogo BG T, Melana SM, Holland J, Mandeli JF, Piloti S, Casalini P, Menard S. Sequences homologous to the MMTV env gene in human breast carcinoma correlate with overexpression of laminin receptor. Clin Cancer Res 1999; 5(8): 2108-11.

Liu X, Kirschenbaum A, Yao S, Stearns ME, Holland J, Claffey K, Levine A. Upregulation of vascular endothelial growth factor by cobalt-induced hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line. Clin Exp Metastasis 1999 17(8):687-94.

Halatsch ME, Botefur IC, Schmidt U, Holland JF, Ohnuma T. Marked inhibition of glioblastoma target cell tumorigenicity in vitro by retrovirus-mediated transfer of a hairpin ribozyme against deletion-mutant epidermal growth factor receptor messenger RNA. J Neurosurg 2000; 92: 297-305.

Liu X, Kirschenbaum A, Yao S, Lee R, Holland J, Levine A. Inhibition of cyclooxygenase-2 suppresses angiogenesis and growth of prostate cancer in vivo. J Urol 2000 Sep; 164: 820-825.