Subspecialty	Endocrinology, Diabetes and Metabolism
Languages	English
Gender	Male
E-mail	mone.zaidi@mountsinai.org
Education and Training	PHD, Royal Postgraduate Medical School
	MBBS, King George's Medical College
	Residency, Medicine-Endoc, Royal Postgraduate Medical School

Education and Training	PHD, Royal Postgraduate Medical School
	MBBS, King George's Medical College
	Residency, Medicine-Endoc, Royal Postgraduate Medical School

Subspecialty	Endocrinology, Diabetes and Metabolism
Languages	English

Research

Dr. Zaidi's research focuses on bone and calcium in areas as diverse as the mode of action of cacitoning, vascular regulation of the osteoclasts, biology of amylin and CGRP, and the mechanism of interleukin-6 action. Early in his career, Dr. Zaidi discovered and characterized the Ca2+-sensing receptor on the osteoclast.

His studies have included, but are not limited to: (a) the use of other cations, in particular Ni2+, to establish Ca2+ release from intracellular stores; (b) delineation of mechanisms of signal transduction, including the demonstration of a pathway for capacitative Ca2+ influx; (c) a complete characterization of di- and trivalent cation action on the osteoclasts; (d) demonstration of the functional effects of Ca2+, particularly effects on acid phosphatase release; (e) demonstration of species variation in Ca2+ response using the quail osteoclasts model; (f) regulation of Ca2+ sensing by physiological influences, including pH, membrane voltage and cacitonin; and (g) the first clear demonstration that the Ca2+ receptor is a ryanodine receptor-gated Ca2+ channel located uniquely in the ostoclast plasma membrane. Dr. Zaidi has also contributed to studies on muscle Ca2+ homeostasis age-associated changes in Ca2+ channel expression, the role of multifunctional antigen, CD38 in osteoclasts regulation, and mechanisms of nuclear Ca2+ homeostasis.

Dr. Zaidi was the first to demonstrate that cacitonin signaled through alternate pathways involving changes in cytosolic Ca2+, a concept that is now proven and well-accepted. He also showed the first effects of amylin on bone resorption.

Shankar VS, Simon BJ, Bax CM, Pazianas M, Moonga B, Adebanjo OA, Zaidi M. Effects of electromagnetic stimulation on the functional responsiveness of isolated rat osteoclasts. J Cell Physiol 1998 Sep; 176(3): 537-44.

Adebanjo OA, Moonga B, Yamate T, Sun L, Minkin C, Abe E, Zaidi M. Mode of action of interleukin-6 on mature osteoclasts. Novel interactions with extracellular Ca2+ sensing in the regulation of osteoclastic bone resorption. J Cell Biol 1998 Sep 7; 142(5): 1347-56.

Adebanjo OA, Moonga B, Haddad JG, Huang CL, Zaidi M. A possible new role for vitamin D-binding protein in osteoclast control: inhibition of extracellular Ca2+ sensing at low physiological concentrations. Biochem Biophys Res Commun 1998 Aug 28; 249(3): 668-71.

Awumey EM, Moonga B, Sodam BR, Koval AP, Adebanjo OA, Kumegawa M, Zaidi M, Epstein S. Molecular and functional evidence for calcineurin-A alpha and beta isoforms in the osteoclast: novel insights into cyclosporin A action on bone resorption. Biochem Biophys Res Commun 1999 Jan 8; 254(1): 248-52.

Zaidi M, Moonga B, Adebanj OA. Novel mechanisms of calcium handling by the osteoclast: A review-hypothesis. Proc Assoc Am Physicians 1999 Jul-Aug 111(4):319-27.

Adebanjo OA, Anandatheerthavarada HK, Koval AP, Moonga B, Biswas G, Sun L, Sodam BR, Bevis P, Huang CL, Epstein S, Lai FA, Avadhani NG, Zaidi M. A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+ homeostasis. Nat Cell Biol 1999 Nov; 1(7): 409-414.

Silverton SF, Adebanjo OA, Moonga B, Awumey EM, Malinski T, Zaidi M. Direct microsensor measurement of nitric oxide production by the osteoclast. Biochem Biophys Res Commun 1999 May 27; 259(1): 73-7.

Zaidi M, Adebanjo OA, Moonga B, Sun L, Huang CL. Emerging insights into the role of calcium ions in osteoclast regulation. J Bone Miner Res 1999 May; 14(5): 669-74.

Sun L, Adebanjo OA, Moonga B, Corisdeo S, Anandatheerthavarada HK, Biswas G, Arakawa T, Hakeda Y, Koval A, Sodam B, Bevis P, Moser AJ, Lai FA, Epstein S, Troen BR, Kumegawa M, Zaidi M. CD38/ADP-ribosyl cyclase: A new role in the regulation of osteoclastic bone resorptionCD38/ADP-ribosyl cyclase: A new role in the regulation of osteoclastic bone resorption. J Cell Biol 1999 Sep 6; 146(5): 1161-72.

Silverton SF, Adebanjo OA, Moonga B, Markham GD, Malinski T, Johnson J, Zaidi M. Measurement of nitric oxide production from single isolated chick osteoclasts using a porphyrinic microsensor. In: Danks J, Dacke CG, Flik G, Gay C, editors. The Comparative Endocrinology of Calcium Regulation. Bristol, BioScientifica Ltd. ; 1999. pp87-92.