Gender	Female
E-mail	stephanie.dahan@mssm.edu
Awards	2009 - 2012 Career Development Award : Lymphoid regulation of epithelial barrier function Role of the immune system on intestinal epithelial cell differentiation and function Crohn's and Colitis Foundation of America
	2002 Travel Award Saccharomyces boulardii interferes with enterohaemorragic E. coli-induced signaling pathways in T84 cells. Journees Francophones de Pathologies Digestives
	1999 - 2002 Research Fellowship Saccharomyces boulardii protection effects and mechanisms against enteropathogenic and enterohaemorragic E. coli intestinal infection Laboratoires Biocodex and the Region Provence-Alpes Cote d'Azur

The mucosal immune system is governed by a unique set of rules and regulations. The local microenvironment dictates the necessity for these differences. Intestinal epithelial cells (IECs) sit at the interface between an antigen-rich lumen and a lymphocyte-rich lamina propria (LP). The crosstalk that occurs between these compartments serves to maintain intestinal homeostasis. IECs have the capacity to talk to LP lymphocytes (LPL), activating populations of unique regulatory T cells. These cells have the capacity to talk back to the epithelium, influencing epithelial cell growth and differentiation. The goal of our research is to understand mechanisms underlying the IEC differentiation induced by LPL. Understanding the normal state will allow us to define the nature of the defects seen in Inflammatory Bowel Disease and potentially develop therapeutic approaches to overcome these defects. Our hypothesis  is that abnormalities in mucosal lymphocytes in Crohn's disease and Ulcerative colitis lead to disordered epithelial cell differentiation, barrier function and subsequent innate and adaptive immune dysfunctions.

Dahan S, Roda G, Mezzanotte L, Caponi A, Roth-Walter F, Pinn D, Mayer L. The defect in CEACAM family member expression in Crohn's disease IECs is regulated by the transcription factor SOX9. IBD; In press.

Dahan S, Roth-Walter F, Martin AP, Arnaboldi P, Mayer L. Lymphoepithelial interactions: a new paradigm. Ann N Y Acad Sci; In press.

Roth-Walter F, Berin MC, Arnaboldi P, Escalante CR, Dahan S, Jensen-Joralim E, Mayer L. Pasteurization of B-lactoglobulin promotes allergic sensitization in mice by enhancing uptake through Peyer's patches. Allergy 2008; 63(7): 882-890.

Dahan S, Roda G, Pinn D, Roth-Walter F, Kamalu O, Martin AP, Mayer L. Epithelial: lamina propria lymphocytes interactions promote epithelial cell differentiation. Gastroenterol 2008; 134: 192-203.

Dahan S, Roth-Walter F, Arnaboldi P, Agarwal S, Mayer L. Epithelial: lymphocytes interactions in the gut. Immunol. Rev 2007; 215: 243-253.

Li H, Nowak-Wegrzyn A, Charlop-Powers Z, Shreffler W, Chehade M, Thomas S, Roda G, Dahan S, Sperber K, Berin MC. Transcytosis of IgE-mediated complexes by CD23a in human intestinal epithelial cells and its role in food allergy. Gastroenterol 2006; 131: 47-58.

Dalmasso G, Loubat A, Dahan S, Calle G, Rampal P, . Saccharomyces boulardii prevents TNF induced apoptosis in EHEC-infected human colonic cell line T84. Res. Microbiol 2006; 157: 456-465.

Dahan S, Dalmasso G, Imbert V, Peyron JF, Rampal P, Czerucka D. Saccharomyces boulardii interferes with Enterohaemorrhagic Escherichia coli-induced signaling pathways in T84 cells. Infect. Immun 2003; 71: 766-773.

Dahan S, Busuttil V, Imbert V, Peyron JF, Rampal P, Czerucka D. Enterohaemorrhagic Escherichia coli induce IL-8 production via activation of MAP Kinases and the transcription factors NK-kB and AP-1 in T84 cells. Infect. Immun 2002; 70: 2304-2310.

Czerucka D, Dahan S, Mograbi B, Rossi B, Rampal P. Implication of MAP Kinases in T84 cell responses to EPEC infection. Infect. Immun 2001; 69: 1298-1305.

Czerucka D, Dahan S, Mograbi B, Rossi B, Rampal P. Saccharomyces boulardii preserves barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli-infected T84 cells. Infect. Immun 2000; 68: 5998-6004.