Gender	Male
E-mail	roberto.sanchez@mssm.edu
Education and Training	Ph.D., The Rockefeller University

Dr. Sanchez is Director of the Biophysics, Structural Biology and Biomathematics Training Area of the Graduate School of Biological Sciences.

Education and Training	Ph.D., The Rockefeller University

Bioinformatics: Computational Structural Biology

Sanchez Lab Web Site

We are interested in developing and applying computational tools for biological problems. Our work is particularly oriented to prediction and analysis of protein structure and its relationship to protein function. Areas of interest include:

• Structure Prediction: Comparative modeling, structure evaluation, domain interactions, protein-protein interaction.
• Structure-Function Relationship: Analysis of protein families, prediction of function from structure, evolution of structure/function.
• Structural Genomics: Computational methods for large-scale protein structure determination.
• Biological Databases: Design and integration of databases for protein structure and function.

Hidalgo ME, Sanchez R, Perez DG, Rodriguez MA, Garcia J, Orozco E. Molecular characterization of the Entamoeba histolytica enolase gene and modelling of the predicted protein. FEMS Microbiol Lett 1997 Mar 15; 148(2): 123-9.

Sanchez R, Sali A. Evaluation of comparative protein structure modeling by MODELLER-3. Proteins 1997; Suppl 1: 50-8.

Sanchez R, Sali A. Advances in comparative protein-structure modelling. Curr Opin Struct Biol 1997 Apr; 7(2): 206-14.

Li E, Pedraza A, Bestagno M, Mancardi S, Sanchez R, Burrone O. Mammalian cell expression of dimeric small immune proteins (SIP). Protein Eng 1997 Jun; 10(6): 731-6.

Sanchez R, Sali A. Large-scale protein structure modeling of the Saccharomyces cerevisiae genome. Proc Natl Acad Sci U S A 1998 Nov 10; 95(23): 13597-602.

Miwa JM, Ibanez-Tallon I, Crabtree GW, Sanchez R, Sali A, Role W, Heintz N. lynx1, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS. Neuron 1999 May; 23(1): 105-14.

Sanchez R, Sali A. Comparative protein structure modeling in genomics. J Comput Phys 1999; 151: 388-401.

Sanchez R, Sali A. Comparative protein structure modeling. Introduction and practical examples with modeller. Methods Mol Biol 2000; 143: 97-129.

Sanchez R, Pieper U, Mirkovic N, De Bakker PI, Wittenstein E, Sali A. MODBASE, a database of annotated comparative protein structure models. Nucleic Acids Res 2000 Jan 1; 28(1): 250-3.

Sanchez R, Pieper U, Melo F, Eswar N, Marti-Renom MA, Madhusudhan MS, Mirkovic N, Sali A. Protein structure modeling for structural genomics. Nat Struct Biol 2000 Nov; 7(Suppl): 986-90.