Gender	Male
E-mail	xuemin.ye@mssm.edu
Education and Training	Ph.D., City University of New York
	M.Sc., University of British Columbia
	B.Sc., Zhongshan University

Education and Training	Ph.D., City University of New York
	M.Sc., University of British Columbia
	B.Sc., Zhongshan University

The laboratory provides service to the Department of Ophthalmology including preparing cryo-sections, and paraffin section, for histological and immunocytochemistry staining in the eye and brain tissues. The lab has access to electronic equipment that includes LEICA EG1160 embedding center, Lab Vision autostainer 360, Bright Cryostat Center. This equipment and lab space has been used to prepare cryo-section and paraffin section frequently for the Department of Ophthalmology. Medical students also use the lab for their training. In addition, we are also testing the method of array tomography.

Dr. Ye researches visual pathology in a family of progressive neurodegenerative disorders called prion diseases in humans and animals. A prion is an abnormal agent that induces folding of normal cellular prion proteins in the brain. The result of infection with prions includes brain damage and, in most cases, a rapidly progressive decline in function, and death. Also known as transmissible spongiform encephalopathies (TSEs), prion diseases in humans include Creutzfeldt-Jakob Disease and Fatal Familial Insomnia.

Dr. Ye is examining the cellular and molecular mechanisms of prion-induced visual pathology. His team has identified histopathological changes in brain visual system in scrapie-infected hamsters comparable to those found in prion-induced human cortical blindness.  A poster of the research results was presented in AVRO meeting in 2007.

Spinner DS, Cho IS, Park SY, Kim J, Meeker HC, Ye X, LaFauci G, Kerr DJ, Flory MJ, Kim BS, Kascsak RB, Wisniewski T, Levis WR, Schuller-Levis G, Carp RI, Park E, Kascsak RJ. Accelerated prion disease pathogenesis in the absence of Toll-like receptor 4 (TLR4)-signaling. J. Virol doi 2008; 10 1128/JVI.00522-08.

Spinner DS, Kascsak RB, LaFauci G, Meeker HC, Ye X, Flory MJ, Kim JI, Schuller-Levis GB, Levis WR, Wisniewski T, Carp RI, Kascsak RJ. CpG oligodeoxynucleotide-enhanced humune response and production of antibodies to prion protein PrPSc in mice immunized with 139A scrapie-associated fibrils. J. Leukocyte Biology 2007; 81: 1374-1385.

LaFauci G, Carp RI, Meeker HC, Ye X, Kim J, Natelli M, Cedeno M, Petersen RB, Rubenstein R. Passage of Chronic Wasting Disease agent into transgenic mice expressing Rocky Mountain Elk PrPC. J Gen Virol 2006; 87: 3773-3780.

Ye X, Kim JI, Meeker HC, Kozlowski P, Kim YS, Rubenstein R, Carp RI. Increased 4-hydroxy-2-nonenal, a major end product of lipid peroxidation, in the brain of senescence accelerated mice SAMP8 and SAMP10. Br. Aging. 2005; 4(2): 13-20.

Ye X, Meeker HC, Kozlowski PB, Wegiel J, Wang K, Imaki H, Carp R. Pathological changes in the liver of senescence accelerated mouse strain (SAMP8): A mouse model for the study of liver diseases. Histology and Histopathology 2004; 19: 1141-1151.

Ye X, Meeker HC, Kozlowski P, Carp RI. Activation of p38 mitogen-activated protein kinase in scrapie-infected SAMP8, SAMR1 AKR and C57BL mice. Brain Aging 2003; 3(2): 19-28.

Ye X, Meeker HC, Scallet A, Carp RI. Comparison of NADPH diaphorase activity in the brains hamsters infected with scrapie strains 139H or 263K or normal hamster brain homogenate. Histol. Histopathol 2001; 16: 997-1003.

Ye X, Rountree RL, Scallet AC, Meeker HC, Carp RI. Evaluation of neurodegeneration in scrapie-infected animals by specific degeneration-selective methods that detect cellular degeneration. Br. Res 2001; 910: 175-178.

Ye X, Carp RI, Schmued LC, Scallet A. Fluoro-Jade and silver methods: application to the neuropathology of scrapie, a transmissible spongiform encephalophathy. Br. Res. Protocols 2001; 8: 104-112.

Ye X, Scallet A, Kascsak RL, Carp RI. Astrocytosis and amyloid deposition in scrapie-infected hamsters. Br. Res. 1998; 809: 277-287.