Gender	Female
E-mail	theresa.chang@mssm.edu
Education and Training	Ph.D., New York University
	Fellow, Aaron Diamond AIDS Research Center, Rockefeller University
	Fellow, Yale University

Education and Training	Ph.D., New York University
	Fellow, Aaron Diamond AIDS Research Center, Rockefeller University
	Fellow, Yale University

Virus-host interaction, viral immunity, HIV, HCV, Cell signaling and gene regulation

Our laboratory is interested in understanding the interaction between virus and immune system at molecular levels using proteomic and functional genomic approaches. We have recently demonstrated that defensins, small antimicrobial peptides, can control HIV infection by direct inactivating the virion and importantly by modulating cell signaling pathways in the target cell. Our current researches focus on dissecting the role of defensins in HIV pathogenesis. We are investigating the mechanisms by which various defensins inhibit or enhance HIV infection as well as how toll-like receptor activation regulates gene expression of defensins and subsequently affects HIV replication. We are also interested in understanding how HIV infection enhances HCV replication at the molecular basis. These studies will provide insights into immune systems in response to viral infection and offer potential novel targets for antiviral drug design.

Chang TL, Peng XB, Fu XY. Interleukin-4 mediates cell growth inhibition through activation of STAT1. J. Biol. Chem 2000; 275: 10212-10217.

Chang TL, Mosoian A, Pine R, Klotman ME, Moore JP. Soluble factor(s) secreted from CD8+ T lymphocytes inhibits human immunodeficiency virus replication through STAT1 activation. J. Virol 2002; 76: 569-581.

Chang TL, Gordon CJ, Roscic-Mrkic B, Power C, Proudfoot AE I, Moore JP M, Trkola A. Interaction of the CC-chemokine RANTES with glycosaminoglycans activates a p44/p42 mitogen-activated protein kinase-dependent signaling pathway and enhances human immunodeficiency virus type 1 infectivity. J. Virol 2002; 76: 2245-2254.

Chang TL, Francois F, Mosoian A, Klotman ME. CAF-mediated human immunodeficiency virus type 1 transcriptional inhibition is distinct from alpha-defensin-1 HIV inhibition. J. Virol 2003; 77: 6777-6784.

Chang TL, Chang CC, Simpson DA, Xu Q, Martin PK, Lagenaur LA, Schoolnik GK, Ho DD, Hillier SL, Holodniy M, Lewicki JA, Lee PP. Inhibition of HIV infectivity by a natural human isolate of Lactobacillus jensenii engineered to express functional two-domain CD4. PNAS 2003; 100: 11672-11677.

Chang T, De Quadros . Vaccines: preventing diseases and protecting health [review]. Viral Immunol 2004; 17: 455-456.

Chang TL, Klotman ME. Defensins: natural anti-HIV peptides. AIDS Rev 2004; 6: 161-168.

Chang T, Vargas, Jr. J, Delportillo A, Klotman ME. Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity. J. Clin Invest 2005; 115: 765-773.

Liu X, Mosoian A, Chang T, Zerhouni-Layachi B, Snyder A, Jarvis GA, Klotman ME. Gonococcal lipooligosaccharide suppresses HIV infection in human primary macrophages through induction of innate immunity. J Infect Dis 2006; 194(6): 751-759.

Klotman ME, Chang TL. Defensins in antiviral immunity. Nature review immunology 2006; 6: 447-456.