Gender	Male
E-mail	christopher.cardozo@mssm.edu
	chris.cardozo@mssm.edu
Education and Training	B.S., University of Wisconsin
	M.D. , University Wisconsin
	Research Fellowship, Mount Sinai School of Medicine
	Fellowship, The Mount Sinai Hospital
	Residency, The Mount Sinai Hospital

Education and Training	B.S., University of Wisconsin
	M.D. , University Wisconsin
	Research Fellowship, Mount Sinai School of Medicine
	Fellowship, The Mount Sinai Hospital
	Residency, The Mount Sinai Hospital

The laboratory is a part of the Spinal Cord Damage Research Center, and of the VA Rehabilitation Research and Development Service Center of Excellence located at the Bronx VA Medical Center. The central theme of our work is to define the molecular mechanisms by which anabolic agents block muscle loss and promote muscle gain. Our ultimate hope is that through such knowledge, novel and more effective treatments can be developed that have the effect to prevent muscle loss. Current areas of focus include: (1) defining molecular mechanisms by which androgens such testosterone induced release of the muscle trophic factor IGF-1. We have defined several androgen response elements bound by the androgen receptor and are currently characterizing these. (2) characterize effects of androgens to suppress expression of the muscle degradation factor MAFbx. This protein is a muscle-specific ubiquitin ligase that is expressed at high levels in muscle loss. We have defined the structure of the MAFbx promotor and shown that expression of this gene is suppressed by androgens. Current efforts are aimed at understanding how such suppression occurs and at determining those muscle loss states where such suppression occurs. (3) Effects of androgens to suppress muscle loss: these studies test whether androgens block muscle loss due to paralysis, and to explain such effects by characterizing changes in muscle gene expression that are attributable to androgens.

Eleuteri AM, Kohanski RA, Cardozo C, Orlowski M. Bovine spleen multicatalytic proteinase complex (proteasome). Replacement of X, Y and Z subunits by LMP7, LMP2, and MECL1 and changes in properties and specificity. J Biol Chem 1997; 272: 11824-11833.

Cardozo C, Kohanski RA. Altered properties of the branched chain amino acid preferring activity contribute to increased cleavages after branched chain residues by the 'immunoproteasome'. J Biol Chem 1998; 273: 16764-16770.

Cardozo C, Michaud C, Orlowski M. Components of the bovine pituitary multicatalytic proteinase complex (proteasome) cleaving bonds after hydrophobic residues. Biochemistry 1999 Jul 27; 38(30): 9768-77.

Wang R, Chait BT, Wolf I, Kohanski RA, Cardozo C. Lysozyme degradation by the bovine multicatalytic proteinase complex (proteasome): evidence for a non-processive mode of degradation. Biochemistry 1999; 38: 14573-14581.

Cardozo C, Wu X, Pan M, Wang H, Fisher EA. The Inhibition of Microsomal Triglyceride Transfer Protein Activity in Rat Hepatoma Cells Promotes Proteasomal and Non-Proteasomal Degradation of Apoprotein B100. Biochemistry 2002; 41: 10105-10114.

Cardozo C, Michaud C. Proteasome-mediated degradation of tau proteins occurs independently of the chymotrypsin-like activity by a non-processive pathway. Arch Biochem Biophys 2002; 408: 103-110.

Cardozo CP, Michaud C, Ost MC, Fliss AE, Yang E, Patterson C, Hall SJ, Caplan AJ. Chip Slows Androgen Receptor Synthesis And Reduces Its Rate Of Degradation. Arch Biochem Biophys 2002; 410: 134-140.

Zhao J, Bauman WA, Huang R, Caplan AJ, Cardozo CP. Oxandrolone blocks glucocorticoid signaling in an androgen receptor dependent manner. Steriods 2004; 69(5): 357-66.

Shabbir A, Distasio S, Zhao J, Cardozo CP, Wolff MS, Caplan AJ. Differential effects of the organochlorine pesticide DDT and its metabolite p, p??-Dde on p-glucoprotein activity and expression. Toxicol Appl Pharmacol 2005; 203: 91-98.