| Gender | Male |
|---|---|
| kevin.kelley@mssm.edu | |
| Education and Training | Ph.D., Johns Hopkins University |
| Postdoctoral Fellowship, Yale University School of Medicine | |
| Awards | 1993 - 1997 Irma T. Hirschl Career Scientist Award |
| 1987 - 1988 Swebilius Cancer Research Award |
|
| 1985 - 1987 Postdoctoral Fellow American Cancer Society |
| Education and Training | Ph.D., Johns Hopkins University |
|---|---|
| Postdoctoral Fellowship, Yale University School of Medicine |
The Mouse Genetics Shared Research Facility (SRF) was established in 1999 to provide the faculty of Mount Sinai with a state-of-the-art facility for the production of novel, genetically manipulated mouse lines. The research efforts of this group include microinjection of gene fragments for production of transgenic mice, microinjection of selected ES cells for the production of gene-targeted mouse lines, rederivations of mouse lines for removal of mouse pathogens, and cryopreservation of mouse gametes. In addition to these research goals, the SRF provides investigators with an outstanding resource for aid with transgene design, protocols for ES cell culture, and general assistance with all phases of mouse genetics. In addition to the goals of the SRF, my collaborative research interests using the mouse as a model system span several areas of developmental biology as evidenced by the following publications.
Hahm S, Mizuno TM, Wu TJ, Wisor JP, Priest CA, Kozak CA, Boozer CN, Peng B, McEvoy RC, Good P, Kelley K, Takahashi JS, Pintar JE, Roberts JL, Mobbs CV, Salton SR. Targeted deletion of the vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron .1999; 23: 537-548.
Friedrich VL, Holstein G Jr, Li X, Gow A, Kelley K, Lazzarini RA. Intracellular distribution of transgenic bacterial-galactosidase in CNS neurons and neuroglia. J Neurosci Res 1993; 36: 88-98.
Kelley K, Friedrich VL, Sonshine A, Hu Y, Lax J, Li J, Drinkwater D, Dressler H, Herrup K. Expression of Thy-1/lacZ fusion genes in the CNS of transgenic mice. Brain Res Mol Brain Res 1994; 24: 261-274.
Kelley K, Ho L, Winger D, Freire-Moar J, Borelli B, Aisen P, Pasinetti GM. Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase 2. Am J Pathol 1999; 155: 995-1004.
Dracheva S, Xu M, Kelley K, Haroutunian V, Holstein GR, Haun S, Silverstein JH, Sealfon SC. Paradoxical behavior of dopamine D1 receptor transgenic mice. Exp Neurol 1999; 157: 169-179.
Stecca B, Southwood CM, Gragerov A, Kelley K, Friedrich VL, Gow A. The evolution of lipophilin genes from invertebrates to tetrapods: DM-20 cannot replace proteolipid protein in CNS myelin. J Neurosci 2000; 1: 4002-4010.
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