Specialty	Neurology
Gender	Male
E-mail	samuel.gandy@mssm.edu
Education and Training	MD, Medical University of South Carolina
	Internship, Internal Medicine, Columbia University College of Physicians & Surgeons
	Residency, Neurology, New York Hospital Cornell University Med Ctr
Awards	2008 Arthur Cherkin Memorial Award in Geriatric Medicine

Sam Gandy, MD, PhD, is Mount Sinai Professor of Alzheimer's Disease Research, Professor of Neurology and Psychiatry, Associate Director of the Mount Sinai Alzheimer's Disease Research Center in New York City, and Chairman Emeritus of the National Medical and Scientific Advisory Council of the Alzheimer's Association. Dr. Gandy is an international expert in the metabolism of the sticky substance called amyloid that clogs the brain in patients with Alzheimer's. In 1989, Gandy and his team discovered the first drugs that could lower formation of amyloid. Dr. Gandy has written more than 150 original papers, chapters and reviews on this topic. Dr. Gandy has received continuous NIH funding for his research on amyloid metabolism since 1986.

Dr. Gandy is a member of the Faculty of 1000 Biology and serves as a Consulting Editor for The Journal of Clinical Investigation.  He also serves on the Editorial Advisory Boards for the journals Public Library of Science-Medicine (PLoSM), Neurodegenerative Diseases, and Current Alzheimer Research.  He is Associate Editor of the journals Molecular Neurodegeneration and Alzheimer Disease and Associated Disorders. From 1996-2006, Dr Gandy was Director of the Cold Spring Harbor Laboratories/Wellcome Trust Annual Summer Course on the Neurobiology of Human Neurological Disorders. In 2000, he became chief organizer for the Cold Spring Harbor Laboratories Bi-Annual Winter Biotechnology Conference on Therapeutic Opportunities in Neurodegenerative Diseases and continues in that role until 2010.
Dr. Gandy has appeared numerous times on television and in print, including:

• Jim Lehrer Newshour
• The CBS Early Show
• NBC Nightly News
• ABC News On Call

In May 2009, Dr. Gandy was featured with other prominent research scientists as GQ's "Rockstars of Science". View the PDF. In addition, Dr. Gandy has spoken before Congress on several occasions (Click to view the PDF of transcript of 5/3/05, PDF of transcript of 3/20/07)

Dr. Gandy received both his MD and PhD at the Medical University of South Carolina. He completed an internship in Internal Medicine at the Columbia University College of Physicians & Surgeons and a residency in Neurology at Cornell University Medical College. Dr. Gandy completed postdoctoral training at The Rockefeller University, where, in 1991, he was appointed assistant professor in the laboratory of Paul Greengard, 2000 Laureate of the Nobel Prize in Physiology or Medicine. From 1992-1997, Gandy was Associate Professor of Neurology and Neuroscience at Cornell University Medical College. From 1997-2001, he was Professor of Psychiatry and of Cell Biology at New York University and The Nathan S. Kline Institute for Psychiatric Research. From 2001-2007, he served as Paul C. Brucker, M.D., Professor of Neuroscience at Jefferson Medical College and Founding Director of the Farber Institute for Neurosciences. In 2007, he assumed his current post as Mount Sinai Professor of Alzheimer's Disease Research at the Mount Sinai School of Medicine.

Education and Training	MD, Medical University of South Carolina
	Internship, Internal Medicine, Columbia University College of Physicians & Surgeons
	Residency, Neurology, New York Hospital Cornell University Med Ctr

Specialty	Neurology

Current Students: John W. Steele IV, Hannah Brautigam

Postdoctoral Fellows: Soong Ho Kim, PhD, Rachel Lane, Ph.D.

Research Personnel: Alex Lublin, Ph.D. (Instructor), Carlos Thomas

Overview:
Dr. Gandy is an international expert in the metabolism of the substance called amyloid that clogs the brain in patients with Alzheimer's. In 1989, Gandy and his team discovered the first drugs that could lower formation of amyloid. Dr. Gandy has written more than 150 original papers, chapters and reviews on this topic. Dr. Gandy has received continuous NIH funding for his research on amyloid metabolism since 1986. Dr. Gandy is Professor of Alzheimer's Disease Research, Professor of Neurology and Psychiatry, and Associate Director of the Mount Sinai Alzheimer's Disease Research Center, and Chair, National Medical and Scientific Advisory Council of the Alzheimer's Association. 

Gandy S, Doeven MK, Poolman B. Alzheimer disease: presenilin springs a leak. Nature Med 2006 Oct; 12(10): 1121-1123.

Small SA, Gandy S. Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis . Neuron 2006 Oct 5; 52(1): 15-31.

Gandy S. The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease . J Clin Invest 2005 May; 115(5): 1121-1129.

Gandy S, Naslund J, Nordstedt C. Alzheimer's disease. Molecular consequences of presenilin-1 mutation. Nature 2001 Jun; 411(6838): 654-656.

Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L, Fried G, Jovanovic JN, Seeger M, Relkin NR, Liao F, Checler F, Buxbaum JD, Chait BT, Thinakaran G, Sisodia SS, Wang R, Greengard P, Gandy S. Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nature Med 1998 Apr; 4(4): 447-451.

Lee MK, Borchelt DR, Kim G, Thinakaran G, Slunt HH, Ratovitski T, Martin LJ, Kittur A, Gandy S, Levey AI, Jenkins N, Copeland N, Price DL, Sisodia SS. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. Nature Med 1997 Jul; 3(7): 756-760.

Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc Natl Acad Sci U S A 1997 May 13; 94(10): 5090-5094.

Xu H, Sweeney D, Wang R, Thinakaran G, Lo AC, Sisodia SS, Greengard P, Gandy S. Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proc Natl Acad Sci U S A 1997 Apr 15; 94(8): 3748-3752.

Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo . Neuron 1996 Nov; 17(5): 1005-1013.

Naslund J, Thyberg J, Tjernberg LO, Wernstedt C, Karlstrom AR, Bogdanovic N, Gandy SE, Lannfelt L, Terenius L, Nordstedt C. Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain . Neuron 1995 Jul; 15(1): 219-228.