Dr. Manini graduated Phi Beta Kappa from MIT, then went on to Stanford Medical School where she was awarded 'Service in Action' recognition by hospital patients. During medical school she won a grant from the American Medical Women's Association to provide international humanitarian aid. She completed residency training in Internal Medicine at Beth Israel Deaconess Medical Center, an affiliate of Harvard Medical School. There she specialized in Primary Care and served as a Chief Medical Resident at the Veterans Affairs Hospital. After residency she practiced as a General Internist in the Boston area, while holding an appointment as Clinical Instructor at Tufts University School of Medicine. Currently Dr. Manini divides her time between Internal Medicine Associates at Mt. Sinai Hospital and Refuah Health Center in Spring Valley, NY where she serves as Medical Director.