The research activities in the Division of Nephrology encompass a wide range of topics with the aim of furthering our understanding of the molecular basis of disease, and developing novel therapeutic approaches to treat diseases of the kidney. Our effort to understand the molecular pathogenesis of disease states enables our progress toward the development and assessment of the therapeutic potential for small molecule, inhibitor peptide, or gene therapy interventions.

Immunomodulation by MHC Class II Peptides
Primary Investigator: Barbara Murphy
FUNDING AGENCY: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Project Period: 01-Apr-01 - 31-Mar-07

The Prevalence, Pathogenesis and Therapy of HIVAN
Primary Investigator: Jonathan Winston
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 15-Mar-02 - 28-Feb-07

Mechanisms of Chronic Allograft Nephropathy in Humans
Primary Investigator: Enver Akalin
FUNDING AGENCY: AMERICAN SOCIETY OF TRANSPLANTATION
Project Period: 01-Jul-02 - 30-Jun-07

Epithelial Gene Expression in HIV-Associated Nephropathy
Primary Investigator: Michael J. Ross
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 30-Sep-02 - 29-Sep-07

Regulation of Transepithelial Transport in PKD
Primary Investigator: Rajeev Rohatgi
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 01-May-04 - 30-Apr-09

Design of Novel Therapeutic Strategies for PKD
Primary Investigator: Patricia Wilson
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 01-Aug-03 - 31-Jul-08

Lentiviral Mediated Gene Transfer to Kidney
Primary Investigator: Gabriele Gusella
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 15-Jul-02 - 31-Jan-07

Mechanisms of Nucleic Acid Uptake by Renal Epithelium
Primary Investigator: Paul Klotman
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 20-Jun-02 - 31-Jan-07

Pathogenesis of HIVAN: the Role of Nef
Primary Investigator: Ci-Jiang He
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 01-Jul-03 - 30-Jun-08

ParainfluenzaItions w/Dendritic Cells
Primary Investigator: Gabriele Gusella
FUNDING AGENCY: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Project Period: 15-Jul-05 - 30-Jun-07

Modeling Renal Development
Primary Investigator: Deborah Hyink
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 01-Dec-03 - 30-Nov-06

Mechanisms of Nucleic Acid Uptake and the Role of cMDH
Primary Investigator: Basil Hanss
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 15-Jan-04 - 31-Dec-08

Frequent Hemodialysis Clinical Trials
Primary Investigator: Brian D. Radbill
FUNDING AGENCY: RENAL RESEARCH INSTITUTE
Project Period: 30-Sep-03 - 31-Aug-07

Proteomic Predictors of AASK Renal Disease Progression
Primary Investigator: Michael Lipkowitz
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 21-May-04 - 30-Apr-07

Cytokine Signaling in Renal Fibrosis
Primary Investigator: Erwin Bottinger
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 01-Feb-04 - 30-Mar-10

Sidekick Proteins in HIV-Associated Nephropathy
Primary Investigator: Lewis Kaufman
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 01-Jul-05 - 30-Jun-10

Mouse Models of Diabetic Nephropathy
Primary Investigator: Erwin Bottinger
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 01-Feb-04 - 31-Aug-07

Bone Marrow Derived Mesangial Cell Progenitors in Aging
Primary Investigator: Gary Striker
FUNDING AGENCY: NATIONAL INSTITUTE ON AGING
Project Period: 01-Mar-05 - 30-Apr-07

Dietary Intervention Evaluating Transport of Urate
Primary Investigator: Mohammed Rafey
FUNDING AGENCY: KIDNEY & UROLOGY FOUNDATION OF AMERICA
Project Period: 01-Jan-06 - 31-Dec-06

Role of Stat3 in HIV Associated Nephropathy Pathogenesis
Primary Investigator: Ting-Chi Lu
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 01-Feb-06 - 31-Jan-08

Towards Molecular Diagnostics of Glomeruler Diseases
Primary Investigator: Erwin Bottinger
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 03-Apr-06 - 28-Feb-11

Cell & Molecular Biological Analysis of Synaptopodin
Primary Investigator: Peter Mundel
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 01-Mar-01 - 28-Feb-11

Genomics of Delayed Graft Function in Kidney Transplant
Primary Investigator: Bernd Schroppel
FUNDING AGENCY: SATELLITE RESEARCH
Project Period: 01-Jul-05 - 30-Jun-08

Synaptopodin: Biogenesis & Plasticity of Spine Apparatus
Primary Investigator: Peter Mundel
FUNDING AGENCY: NATIONAL INSTITUTE ON DRUG ABUSE
Project Period: 01-Mar-05 - 28-Feb-09

Frailty Older Patients w/Chronic Kidney Disease
Primary Investigator: Mark Swidler
FUNDING AGENCY: AMERICAN SOCIETY OF NEPHROLOGY
Project Period: 01-Jul-05 - 30-Jun-07

Empire Clinical ResearchPrimary Investigator Program
Primary Investigator: Christina Wyatt
FUNDING AGENCY: NEW YORK STATE
Project Period: 01-Jul-05 - 30-Jun-07

Allopurinol & Thiazides Control Hypertension Trial
Primary Investigator: Mohammed Rafey
FUNDING AGENCY: AMGEN NEPHROLOGY FELLOWSHIP PROGRAM
Project Period: 01-Jul-05 - 30-Jun-06

Role of B7-1 in Prodocytes/Pathogenesis of Proteinuria
Primary Investigator: Peter Mundel
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 01-Feb-05 - 31-Mar-09

An In Vitro Model for Evaluation of IC Therapies
Primary Investigator: Peter Mundel
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 01-Feb-05 - 31-Aug-06

AASK Cohort Study
Primary Investigator: Michael Lipkowitz
FUNDING AGENCY: NATIONAL HEART, LUNG & BLOOD INSTITUTE
Project Period: 19-Aug-94 - 30-Jun-07

Analysis of Cystogenic Mechanisms of Polycystin-1
Primary Investigator: Gabriele Gusella
FUNDING AGENCY: POLYCYSTIC KIDNEY DISEASE FOUNDATION
Project Period: 01-Jan-06 - 31-Dec-06

FAT10, Candidate Gene/Epithelial Apoptosis/HIV Nephropathy
Primary Investigator: Michael J. Ross
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 15-May-06 - 30-Apr-08

Genomics of Chronic Renal Allograft
Primary Investigator: Barbara Murphy
FUNDING AGENCY: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Project Period: 15-Aug-06 - 31-Jul-11

Molecular Characterization of Dendrin
Primary Investigator: Katsuhiko Asanuma
FUNDING AGENCY: NATIONAL KIDNEY FOUNDATION
Project Period: 01-Feb-05 - 30-Jun-06

Role of Peroxisomal Proteins Diabetic Mouse Models
Primary Investigator: Stefanie Krick
FUNDING AGENCY: NATIONAL KIDNEY FOUNDATION OF NY/NJ
Project Period: 01-Jul-06 - 30-Jun-08

The Role of VEGF in Podocyte Injury Induced by HIV
Primary Investigator: Sonal Shah
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 01-Jul-06 - 30-Jun-08

Molecular Basis of Renal Diseases
Primary Investigator: Barbara Murphy
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 01-Jul-98 - 30-Jun-09

Pathogenesis of HIV-Associated Nephropathy
Primary Investigator: Paul Klotman
FUNDING AGENCY: NATIONAL INSTITUTE OF DIABETES, DIGESTIVE AND KIDNEY DISEASES
Project Period: 15-Sep-99 - 30-Jun-09