The Division of Hematology and Medical Oncology of the Department of Medicine represents the merger of two rich traditions of our institution. The faculty of the former Division of Hematology made a number of important contributions in the development of blood banking, the understanding of the pathophysiology of polycythemia vera, the understanding of the fundamental role of tissue factor in blood clotting, and the development of new therapies for sickle cell disease and hemophilia. The faculty in the former Division of Medical Oncology at Mount Sinai have made critical contributions to the development of combination chemotherapy for solid tumors and leukemia, the development of differentiation therapy for cancer, the use of growth factors in the support of cancer patients, and the introduction of a new therapy for myelodysplasia. In 2002 these two veins of medical expertise were combined in one of the largest clinical and research divisions in the School of Medicine.

Major Division Programs

• Liver and Gastrointestinal Cancer
• Lung and Head and Neck Cancer
• Experimental Therapeutics in Hematological Malignancies, with an emphasis on reactivation of gene expression in these diseases
• Stem Cell Transplantation with an emphasis on reduced intensity therapy
• The Molecular Basis of Normal and Malignant Blood Development
• Aberrant Signal Transduction in Cancer
• Genomic Alterations in Cancer
• Gene Therapy Approaches to Hemophilia
• Differentiation Therapy of Cancer
• Molecular Pathology of Breast Cancer