Specialty	Internal Medicine
Subspecialty	Nephrology
Gender	Male
E-mail	paul.klotman@mssm.edu
Education and Training	MD, Indiana University
	B.S., University of Michigan
	Chief Medical Resident, Duke University Medical Center
	Residency, Internal Medicine, Duke University Hospital
	Fellowship, Nephrology, Duke University Hospital
Awards	2009 Special Recognition Award The Mount Sinai Medical Center

Paul Klotman, M.D., Chairman of the Samuel Bronfman Department of Medicine and Murray M. Rosenberg Professor of Medicine is one of the world's leading experts on the actions of HIV in the kidney. His achievements in research include developing the first small animal model of HIV associated nephropathy (HIVAN) using transgenic techniques, demonstrating that HIV directly causes HIVAN, discovering that HIV can be found in human renal epithelium, proving that the kidney is a reservoir for replicating virus and that the renal epithelium serves as a compartment distinct from peripheral blood.

As Chief of the Division of Nephrology at Mount Sinai from 1994 through 2001 he led the Division through a period of growth including greatly expanding its research portfolio, recruiting outstanding new faculty and enhancing the fellowship program.

In 2001 he was selected to be Chairman of the Samuel Bronfman Department of Medicine. Under his leadership, the Department has risen to be among the top twenty in the country in terms of funding from the National Institutes of Health, redesigned the curriculum of the residency program to create one of the top medical residencies in the country, created many clinical programs to bring state-of-the-art care to patients, and branched out into new areas in both research and patient care.

As a teacher and mentor, Dr. Klotman has also been extremely successful. He has trained 20 clinical fellows, postdoctoral fellows, and students in his laboratory since 1984 and his trainees include three division chiefs, several full professors and many funded investigators in academic programs and industry.

His laboratory has received awards from the American Federation for Clinical Research and he has been elected to both the American Society of Clinical Investigation and the Association of American Physicians. He is on the editorial boards of national and international journals and has served on and chaired numerous study sections including those from the National Institutes of Health, the American Heart Association, the National Kidney Foundation, and the VA research service.

Dr. Klotman received his M.D. from Indiana University and then trained in medicine and nephrology at Duke University Medical Center. He remained at Duke as a faculty member, rising to the rank of Associate Professor of Medicine before moving to the NIH where he became Chief of the Molecular Medicine Section in the Laboratory of Developmental Biology and later Chief of the Viral Pathogenesis Laboratory in the NIDR/NIH. In 1994, he joined the faculty at Mount Sinai School of Medicine.

Paul Klotman, MD is actively engaged in Panthera, an organization dedicated to the conservation of wild cats and was recently honored for his contributions to cat conservation at a Panthera reception. Find out more in Inside Mount Sinai.

Curriculum Vitae: Curriculum Vitae

Education and Training	MD, Indiana University
	B.S., University of Michigan
	Chief Medical Resident, Duke University Medical Center
	Residency, Internal Medicine, Duke University Hospital
	Fellowship, Nephrology, Duke University Hospital
Board Certification	Nephrology
	Internal Medicine

Specialty	Internal Medicine
Subspecialty	Nephrology
Board Certification	Nephrology
	Internal Medicine

Understanding the molecular basis for the pathogenesis of HIV associated nephropathy

My laboratory is focused on understanding host susceptibility to renal disease. Because HIV associated renal disease so specifically targets Blacks and Blacks are at greater risk for renal disease of all causes, we have explored the mechanisms by which HIV induces renal disease. The goal is to define the molecular pathways of pathogenesis, host susceptibility, and genetic modifiers.

To that end, we developed the first small animal model of HIV associated nephropathy (HIVAN) using transgenic techniques. Our laboratory was the first to demonstrate that HIV directly causes HIVAN, that HIV can be found in human renal epithelium, that the kidney is a reservoir for replicating virus and that the renal epithelium serves as a compartment distinct from peripheral blood.

We have used functional genomic strategies to identify downstream genes that respond to HIV-1 in the infected cellular compartments. This approach has led to the identification of novel candidates for renal pathogenesis. Recently, we identified a novel member of the small leucine rich repeat family, Podocan, that is abundantly expressed in HIVAN glomerular sclerotic plaques. And we have found that the sidekick family, which mediates homophilic interactions, plays a role in both renal development and in HIV associated nephropathy. Work from our laboratory has defined the pathways induced by HIV gene expression that lead to cellular proliferation and our laboratory is now also exploring mechanisms of cellular apoptosis induced by HIV. Finally, we are exploring the role that the host genetic background plays in modulating the phenotypic expression of disease.

Pathogenesis of HIV-Associated Nephropathy Research Program

Marras D, Bruggeman LA, Gao F, Tanji N, Mansukhani MM, Cara A, Ross MD, Gusella GL, Benson G, D'Agati VD, Hahn BH, Klotman M, Klotman PE. Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy. Nat Med 2002 May; 8(5): 522-526.

Ross MD, Bruggeman LA, Hanss B, Sunamoto M, Marras D, Klotman ME, Klotman PE. Podocan; a novel small leucine-rich repeat protein expressed in the sclerotic glomeruli of experimental HIV associated nephropathy. J Biol Chem 2003 Aug 29; 278(35): 33248-33255.

Gharavi AG, Ahmad T, Wong RD, Hooshyar R, Vaughn J, Oller S, Frankel RZ, Bruggeman LA, D'Agati VD, Klotman PE, Lifton RP. Mapping a locus for susceptibility to HIV-1 associated nephropathy to mouse chromosome 3. Proc Natl Acad Sci USA 2004 Feb 24; 101(8): 2488-2493.

Kaufman L, Hayashi K, Ross MD, Ross MJ, Klotman PE. Sidekick expression is upregulated in glomeruli in HIV associated nephropathy. J Am Soc Nephrol 2004 Jul; 15(7): 1721-1730.

He JC, Husain M, Sunamoto M, D'Agati VD, Klotman ME, Iyengar R, Klotman PE. Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. J Clin Invest 2004 Sep; 114(5): 643-651.

Hayashi K, Kaufman L, Ross MD, Klotman PE. Definition of the critical domains required for homophilic targeting of mouse sidekick molecules. FASEB J 2005 Apr; 19(6): 614-616.

Husain M, D'Agati VD, He JC, Klotman ME, Klotman PE. HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. AIDS 2005 Nov 18; 19(17): 1975-1980.